abstract：:In treatment planning we depend upon accurate knowledge of geometric and range uncertainties. If the uncertainty model is inaccurate then the plan will produce under-dosing of the target and/or overdosing of OAR. We aim to provide a method for which centre and site-specific population range uncertainty due to inter-fr...

journal_title：Physics in medicine and biology

authors： Holloway SM,Holloway MD,Thomas SJ

更新日期：2017-12-19 00:00:00

abstract：:Modern effort in radiotherapy to address the challenges of tumor localization and motion has led to the development of MRI guided radiotherapy technologies. Accurate dose calculations must properly account for the effects of the MRI magnetic fields. Previous work has investigated the accuracy of a deterministic linear...

journal_title：Physics in medicine and biology

authors： Zelyak O,Fallone BG,St-Aubin J

更新日期：2017-12-14 00:00:00

abstract：:A multimodal micro-computed tomography (CT) and multi-spectral structured light imaging (SLI) system is introduced and systematically analyzed to test its feasibility to aid in margin delineation during breast conserving surgery (BCS). Phantom analysis of the micro-CT yielded a signal-to-noise ratio of 34, a contrast ...

journal_title：Physics in medicine and biology

authors： McClatchy DM,Rizzo EJ,Meganck J,Kempner J,Vicory J,Wells WA,Paulsen KD,Pogue BW

更新日期：2017-11-10 00:00:00

abstract：:Optimization-based algorithms for image reconstruction in multispectral (or photon-counting) computed tomography (MCT) remains a topic of active research. The challenge of optimization-based image reconstruction in MCT stems from the inherently non-linear data model that can lead to a non-convex optimization program f...

journal_title：Physics in medicine and biology

authors： Chen B,Zhang Z,Sidky EY,Xia D,Pan X

更新日期：2017-11-02 00:00:00

abstract：:The accurate determination of mean ionization potential (I m) has the potential to reduce range uncertainty based margins and therefore allow for more focal treatments in proton radiotherapy. Many methods have been proposed to reduce uncertainty in I m and stopping power ratios (SPR), each with varying degrees of accu...

journal_title：Physics in medicine and biology

authors： Sudhyadhom A

更新日期：2017-10-27 00:00:00

abstract：:Microbeam radiation therapy (MRT) is a treatment approach in radiation therapy where the treatment field is spatially fractionated into arrays of a few tens of micrometre wide planar beams of unusually high peak doses separated by low dose regions of several hundred micrometre width. In preclinical studies, this treat...

journal_title：Physics in medicine and biology

authors： Debus C,Oelfke U,Bartzsch S

更新日期：2017-10-19 00:00:00

abstract：:Dual spectral computed tomography (DSCT) has a superior material distinguishability than the conventional single spectral computed tomography (SSCT). However, the decomposition process is an illposed problem, which is sensitive to noise. Thus, the decomposed image quality is degraded, and the corresponding signal-to-n...

journal_title：Physics in medicine and biology

authors： Wang Q,Zhu Y,Yu H

更新日期：2017-10-19 00:00:00

abstract：:Lung 4D computed tomography (4D-CT), which is a time-resolved CT data acquisition, performs an important role in explicitly including respiratory motion in treatment planning and delivery. However, the radiation dose is usually reduced at the expense of inter-slice spatial resolution to minimize radiation-related heal...

journal_title：Physics in medicine and biology

authors： Fang S,Wang H,Liu Y,Zhang M,Yang W,Feng Q,Chen W,Zhang Y

更新日期：2017-10-03 00:00:00

abstract：:In this work, a methodology for using a smartphone camera, in conjunction with a light-tight box operating in reflective transmission mode, is investigated as a proof of concept for use as a film dosimetry system. An imaging system was designed to allow the camera of a smartphone to be used as a pseudo densitometer. T...

journal_title：Physics in medicine and biology

authors： Aland T,Jhala E,Kairn T,Trapp J

更新日期：2017-10-03 00:00:00

abstract：:Radiation therapy treatment planning requires an incorporation of uncertainties in order to guarantee an adequate irradiation of the tumor volumes. In current clinical practice, uncertainties are accounted for implicitly with an expansion of the target volume according to generic margin recipes. Alternatively, it is p...

journal_title：Physics in medicine and biology

authors： Mescher H,Ulrich S,Bangert M

更新日期：2017-09-05 00:00:00

abstract：:Oxygen ([Formula: see text]) ions are a potential alternative to carbon ions in ion beam therapy. Their enhanced linear energy transfer indicates a higher relative biological effectiveness and a reduced oxygen enhancement ratio. Due to the limited availability of [Formula: see text] ion beams, Monte Carlo (MC) transpo...

journal_title：Physics in medicine and biology

authors： Resch AF,Fuchs H,Georg D

更新日期：2017-09-05 00:00:00

abstract：:An important challenge in real-world biomedical applications of x-ray phase contrast imaging (XPCI) techniques is the efficient use of the photon flux generated by an incoherent and polychromatic x-ray source. This efficiency can directly influence dose and exposure time and ideally should not affect the superior cont...

journal_title：Physics in medicine and biology

authors： Saghamanesh S,Aghamiri SM,Kamali-Asl A,Yashiro W

更新日期：2017-09-01 00:00:00

abstract：:We propose a regularized least-squares method for reconstructing 2D velocity vector fields within the left ventricular cavity from single-view color Doppler echocardiographic images. Vector flow mapping is formulated as a quadratic optimization problem based on an [Formula: see text]-norm minimization of a cost functi...

journal_title：Physics in medicine and biology

authors： Assi KC,Gay E,Chnafa C,Mendez S,Nicoud F,Abascal JFPJ,Lantelme P,Tournoux F,Garcia D

更新日期：2017-08-11 00:00:00

abstract：:The relative stopping power (RSP) uncertainty is the largest contributor to the range uncertainty in proton therapy. The purpose of this work was to develop a systematic method that yields accurate and patient-specific RSPs by combining (1) pre-treatment x-ray CT and (2) daily proton radiography of the patient. The me...

journal_title：Physics in medicine and biology

authors： Collins-Fekete CA,Brousmiche S,Hansen DC,Beaulieu L,Seco J

更新日期：2017-08-03 00:00:00

abstract：:We report on a radiographic measurement of an ex vivo human knee using a grating-based phase-contrast imaging setup and a medical x-ray tube at a tube voltage of 70 kV. The measurement has been carried out using a Talbot-Lau setup that is suitable to achieve a high visibility in the energy regime of medical imaging. I...

journal_title：Physics in medicine and biology

authors： Horn F,Gelse K,Jabari S,Hauke C,Kaeppler S,Ludwig V,Meyer P,Michel T,Mohr J,Pelzer G,Rieger J,Riess C,Seifert M,Anton G

更新日期：2017-08-01 00:00:00

abstract：:This study aims to develop and test software for assessing and reporting doses for standard patients undergoing computed tomography (CT) examinations in a 320 detector-row cone-beam scanner. The software, called SimDoseCT, is based on the Monte Carlo (MC) simulation code, which was developed to calculate organ doses a...

journal_title：Physics in medicine and biology

authors： Cros M,Joemai RMS,Geleijns J,Molina D,Salvadó M

更新日期：2017-07-17 00:00:00

abstract：:Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms wh...

journal_title：Physics in medicine and biology

authors： Xie T,Kuster N,Zaidi H

更新日期：2017-07-13 00:00:00

abstract：:Reducing radiation dose in dual energy computed tomography (DECT) is highly desirable but it may lead to excessive noise in the filtered backprojection (FBP) reconstructed DECT images, which can inevitably increase the diagnostic uncertainty. To obtain clinically acceptable DECT images from low-mAs acquisitions, in th...

journal_title：Physics in medicine and biology

authors： Zhang H,Zeng D,Lin J,Zhang H,Bian Z,Huang J,Gao Y,Zhang S,Zhang H,Feng Q,Liang Z,Chen W,Ma J

更新日期：2017-07-07 00:00:00

abstract：:Intra-fractional motion is a concern during prostate radiation therapy, as it may cause deviations between planned and delivered radiation doses. Because accurate motion information during treatment delivery is critical to address dose deviation, we developed the projection marker matching method (PM3), a novel method...

journal_title：Physics in medicine and biology

authors： Chi Y,Rezaeian NH,Shen C,Zhou Y,Lu W,Yang M,Hannan R,Jia X

更新日期：2017-07-07 00:00:00

abstract：:With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the ...

journal_title：Physics in medicine and biology

authors： Tao L,Zhu K,Zhu J,Xu X,Lin C,Ma W,Lu H,Zhao Y,Lu Y,Chen JE,Yan X

更新日期：2017-07-07 00:00:00

abstract：:The scope of this work was to develop a synthetic single crystal diamond dosimeter (SCDD-Pro) for accurate relative dose measurements of clinical proton beams in water. Monte Carlo simulations were carried out based on the MCNPX code in order to investigate and reduce the dose curve perturbation caused by the SCDD-Pro...

journal_title：Physics in medicine and biology

authors： Moignier C,Tromson D,de Marzi L,Marsolat F,García Hernández JC,Agelou M,Pomorski M,Woo R,Bourbotte JM,Moignau F,Lazaro D,Mazal A

更新日期：2017-07-07 00:00:00

abstract：:Ring artifacts in cone beam computed tomography (CBCT) images are caused by pixel gain variations using flat-panel detectors, and may lead to structured non-uniformities and deterioration of image quality. The purpose of this study is to propose a method of general ring artifact removal in CBCT images. This method is ...

journal_title：Physics in medicine and biology

authors： Liang X,Zhang Z,Niu T,Yu S,Wu S,Li Z,Zhang H,Xie Y

更新日期：2017-07-07 00:00:00

abstract：:Medulloblastoma treatment involves irradiation of the entire central nervous system, i.e. craniospinal irradiation (CSI). This is associated with the significant exposure of large volumes of healthy tissue and there is growing concern regarding treatment-associated side effects. The current study compares out-of-field...

journal_title：Physics in medicine and biology

authors： De Saint-Hubert M,Verellen D,Poels K,Crijns W,Magliona F,Depuydt T,Vanhavere F,Struelens L

更新日期：2017-07-07 00:00:00

abstract：:Usually, Monte Carlo models are validated against experimental data. However, models of multiple Coulomb scattering (MCS) in the Gaussian approximation are exceptional in that we have theories which are probably more accurate than the experiments which have, so far, been done to test them. In problems directly sensiti...

journal_title：Physics in medicine and biology

authors： Makarova A,Gottschalk B,Sauerwein W

更新日期：2017-07-06 00:00:00

abstract：:As known, in cancer therapy with ion beams the relative biological effectiveness (RBE) of ions changes in the course of their propagation in tissues. Such changes are caused not only by increasing the linear energy transfer (LET) of beam particles with the penetration depth towards the Bragg peak, but also by nuclear ...

journal_title：Physics in medicine and biology

authors： Dewey S,Burigo L,Pshenichnov I,Mishustin I,Bleicher M

更新日期：2017-06-27 00:00:00

abstract：:The goal of this study is to demonstrate the feasibility of a novel non-coplanar-arc optimization algorithm (CyberArc). This method aims to reduce the delivery time of conventional CyberKnife treatments by allowing for continuous beam delivery. CyberArc uses a 4 step optimization strategy, in which nodes, beams, and c...

journal_title：Physics in medicine and biology

authors： Kearney V,Cheung JP,McGuinness C,Solberg TD

更新日期：2017-06-26 00:00:00

abstract：:For proton therapy, an accurate conversion of CT HU to relative stopping power (RSP) is essential. Validation of the conversion based on real tissue samples is more direct than the current practice solely based on tissue substitutes and can potentially address variations over the population. Based on a novel dose exti...

journal_title：Physics in medicine and biology

authors： Zhang R,Baer E,Jee KW,Sharp GC,Flanz J,Lu HM

更新日期：2017-06-23 00:00:00

abstract：:Online adaptive radiation therapy (ART) based on real-time magnetic resonance imaging represents a paradigm-changing treatment scheme. However, conventional quality assurance (QA) methods based on phantom measurements are not feasible with the patient on the treatment couch. The purpose of this work is to develop a fa...

journal_title：Physics in medicine and biology

authors： Wang Y,Mazur TR,Park JC,Yang D,Mutic S,Li HH

更新日期：2017-06-21 00:00:00

abstract：:A new function to treat tetrahedral-mesh geometry was implemented in the particle and heavy ion transport code systems. To accelerate the computational speed in the transport process, an original algorithm was introduced to initially prepare decomposition maps for the container box of the tetrahedral-mesh geometry. Th...

journal_title：Physics in medicine and biology

authors： Furuta T,Sato T,Han MC,Yeom YS,Kim CH,Brown JL,Bolch WE

更新日期：2017-06-21 00:00:00

abstract：:It has been reported that acoustic waves are generated when a high-energy pulsed proton beam is deposited in a small volume within tissue. One possible application of proton-induced acoustics is to get real-time feedback for intra-treatment adjustments by monitoring such acoustic waves. A high spatial resolution in ul...

journal_title：Physics in medicine and biology

authors： Kipergil EA,Erkol H,Kaya S,Gulsen G,Unlu MB

更新日期：2017-06-21 00:00:00

abstract：:Conventional molecular assessment of tissue through histology, if adapted to fresh thicker samples, has the potential to enhance cancer detection in surgical margins and monitoring of 3D cell culture molecular environments. However, in thicker samples, substantial background staining is common despite repeated rinsing...

journal_title：Physics in medicine and biology

authors： Xu X,Wang Y,Xiang J,Liu JTC,Tichauer KM

更新日期：2017-06-21 00:00:00

abstract：:The use of deformable image registration methods in the context of adaptive radiotherapy leads to uncertainties in the simulation of the administered dose distributions during the treatment course. Evaluation of these methods is a prerequisite to decide if a plan adaptation will improve the individual treatment. Curre...

journal_title：Physics in medicine and biology

authors： Teske H,Bartelheimer K,Meis J,Bendl R,Stoiber EM,Giske K

更新日期：2017-06-21 00:00:00

abstract：:Effective use of the [Formula: see text] decay chain in targeted internal radioimmunotherapy requires the retention of both [Formula: see text] and progeny isotopes at the target site. Imaging-based pharmacokinetic tests of these pharmaceuticals must therefore separately yet simultaneously image multiple isotopes that...

journal_title：Physics in medicine and biology

authors： Robertson AKH,Ramogida CF,Rodríguez-Rodríguez C,Blinder S,Kunz P,Sossi V,Schaffer P

更新日期：2017-06-07 00:00:00

abstract：:Proton therapy is very sensitive to daily density changes along the pencil beam paths. The purpose of this study is to develop and evaluate an automated method for adaptation of IMPT plans to compensate for these daily tissue density variations. A two-step restoration method for 'densities-of-the-day' was created: (1)...

journal_title：Physics in medicine and biology

authors： Jagt T,Breedveld S,van de Water S,Heijmen B,Hoogeman M

更新日期：2017-06-07 00:00:00

abstract：:Four dimensional cone beam computed tomography (4DCBCT) uses a constant gantry speed and imaging frequency that are independent of the patient's breathing rate. Using a technique called respiratory motion guided 4DCBCT (RMG-4DCBCT), we have previously demonstrated that by varying the gantry speed and imaging frequency...

journal_title：Physics in medicine and biology

authors： O'Brien RT,Stankovic U,Sonke JJ,Keall PJ

更新日期：2017-06-07 00:00:00

abstract：:Awake and/or freely moving small animal single photon emission imaging allows the continuous study of molecules exhibiting slow kinetics without the need to restrain or anaesthetise the animals. Estimating motion free projections in freely moving small animal planar imaging can be considered as a limited angle tomogra...

journal_title：Physics in medicine and biology

authors： Angelis GI,Ryder WJ,Gillam JE,Boisson F,Kyme AZ,Fulton RR,Meikle SR,Kench PL

更新日期：2017-05-21 00:00:00

abstract：:The aim of this study was to systematically investigate the influence of the inter- and intra-observer segmentation variation of tumors and organs at risk on the simulated temperature coverage of the target. CT scans of six patients with tumors in the pelvic region acquired for radiotherapy treatment planning were use...

journal_title：Physics in medicine and biology

authors： Aklan B,Hartmann J,Zink D,Siavooshhaghighi H,Merten R,Putz F,Ott O,Fietkau R,Bert C

更新日期：2017-05-08 00:00:00

abstract：:Multi-atlas segmentation (MAS) has been widely used to automate the delineation of organs at risk (OARs) for radiotherapy. Label fusion is a crucial step in MAS to cope with the segmentation variabilities among multiple atlases. However, most existing label fusion methods do not consider the potential dosimetric impac...

journal_title：Physics in medicine and biology

authors： Chang J,Tian Z,Lu W,Gu X,Chen M,Jiang SB

更新日期：2017-05-07 00:00:00

abstract：:The purpose of this study is to develop an adaptive prior knowledge guided image estimation technique to reduce the scan angle needed in the limited-angle intrafraction verification (LIVE) system for 4D-CBCT reconstruction. The LIVE system has been previously developed to reconstruct 4D volumetric images on-the-fly du...

journal_title：Physics in medicine and biology

authors： Zhang Y,Yin FF,Zhang Y,Ren L

更新日期：2017-05-07 00:00:00

abstract：:A 3D anatomical computational model is developed to assess thermal effects due to exposure to the electromagnetic field required to power a new investigational active implantable microvalve for the treatment of glaucoma. Such a device, located in the temporal superior eye quadrant, produces a filtering bleb, which is ...

journal_title：Physics in medicine and biology

authors： Schaumburg F,Guarnieri FA

更新日期：2017-05-07 00:00:00